Why the study?
Does nicardipine reduce intra-arterial pressure and alter baroreflex sensitivity in patients with essential hypertension?
Population
8 patients with essential hypertension
Comparison
Nicardipine hydrochloride vs Control period (baseline before treatment)
Design
Cohort
Follow-up
at least 2 months
Authors
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Supports acute/chronic BP reduction with nicardipine without baroreflex sensitivity change; leaves open set-point resetting in essential hypertension.
Does nicardipine reduce intra-arterial pressure and alter baroreflex sensitivity in patients with essential hypertension?
Nicardipine effectively lowers blood pressure in essential hypertension, with chronic therapy leading to a resetting of the baroreflex set point that normalizes heart rate without altering baroreflex sensitivity.
Young et al. (1984) studied this question.
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