What question did this study set out to answer?

The study aims to evaluate the effects of nicardipine on blood pressure and renal hemodynamics under acute hypertension induced by norepinephrine and angiotensin II.

January 1, 1987Japanese Heart JournalOpen Access

Effects of nicardipine on the systemic and renal hemodynamics in acutely elevated blood pressure induced by vasoactive agents in conscious rabbits.

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Why the study?

Does nicardipine improve systemic and renal hemodynamics in rabbits with acutely elevated blood pressure induced by norepinephrine or angiotensin II?

Key Points

The study aims to evaluate the effects of nicardipine on blood pressure and renal hemodynamics under acute hypertension induced by norepinephrine and angiotensin II.
Examined conscious rabbits with blood pressure elevation induced by norepinephrine and angiotensin II.
Administered nicardipine intravenously and intrarenally at a dose of 1 microgram/kg.
Measured changes in mean arterial pressure, heart rate, and renal blood flow.
Norepinephrine increased mean arterial pressure from 84 to 118 mmHg; renal blood flow decreased by 45%.
Intravenous and intrarenal nicardipine reduced mean arterial pressure significantly, with intrarenal showing a greater effect (16 mmHg vs 11 mmHg, p<0.05).
Renal nerve denervation had no significant effect in norepinephrine cases but negated the benefit of intrarenal nicardipine in angiotensin II cases.

Structured PICO

Does nicardipine improve systemic and renal hemodynamics in rabbits with acutely elevated blood pressure induced by norepinephrine or angiotensin II?

Population

Female Japanese white rabbits weighing between 2.4 and 3.3 kg, with acutely elevated blood pressure induced by norepinephrine or angiotensin II.

Intervention

Nicardipine (1 microgram/kg) administered intravenously or intrarenally.

Comparator

Baseline measurements before nicardipine injection, and comparison between intravenous vs. intrarenal administration, as well as renally denervated vs. non-denervated animals.

Outcome

Changes in mean arterial pressure, heart rate, and renal blood flow.surrogate

Nicardipine effectively reduces acutely elevated blood pressure caused by norepinephrine or angiotensin II, with the renal vasculature playing a particularly important role in mediating the depressor response in angiotensin II-induced hypertension.

Discussion

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Implication

Intrarenal nicardipine may enhance BP reduction in angiotensin II hypertension models; leaves open human translation and targeted therapy.

Cite This Study

Matsukawa et al. (1987) studied this question.

synapsesocial.com/papers/6a737f5ee7786f1b8071af95 https://doi.org/10.1536/ihj.28.435

Topics

Hypertension management

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Implication

Intrarenal nicardipine may enhance BP reduction in angiotensin II hypertension models; leaves open human translation and targeted therapy.

Effects of nicardipine on the systemic and renal hemodynamics in acutely elevated blood pressure induced by vasoactive agents in conscious rabbits.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Effects of nicardipine on the systemic and renal hemodynamics in acutely elevated blood pressure induced by vasoactive agents in conscious rabbits.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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