Why the study?
Does nicardipine improve renal function and alter plasma renin activity and aldosterone concentration in patients with mild-to-moderate essential hypertension?
Population
n=7 patients with mild-to-moderate essential hypertension
Comparison
Nicardipine 20 or 40 mg oral t.i.d. for 4 weeks vs Placebo
Design
Other
Follow-up
4 weeks
Authors
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Nicardipine may enhance renal hemodynamics in mild-to-moderate hypertension; leaves open effects on clinical outcomes and renin-aldosterone axis.
Does nicardipine improve renal function and alter plasma renin activity and aldosterone concentration in patients with mild-to-moderate essential hypertension?
In patients with mild-to-moderate essential hypertension, 4 weeks of oral nicardipine improved renal hemodynamics and lowered blood pressure without increasing plasma aldosterone.
Baba et al. (1987) studied this question.
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