Key result
Nicardipine produced a greater lowering of blood pressure in hypertensive subjects compared with normals and significantly increased sodium excretion in all subjects.
Why the study?
Does nicardipine affect blood pressure and renal function differently in hypertensive patients with impaired renal function compared to normal subjects?
Does nicardipine affect blood pressure and renal function differently in hypertensive patients with impaired renal function compared to normal subjects?
Nicardipine effectively lowers blood pressure and increases sodium excretion in hypertensive patients with renal impairment, though its clearance is decreased in this population.
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May warrant dose caution in renal impairment despite BP efficacy; leaves open differential renal effects versus normals.
Lee et al. (1986) studied Hypertension with impaired renal function. Nicardipine vs. Normal subjects was evaluated on Pharmacokinetics, blood pressure, and renal function. Nicardipine produced a greater lowering of blood pressure in hypertensive subjects compared with normals and significantly increased sodium excretion in all subjects.
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