Why the study?
Does chronic nicardipine therapy maintain the acute improvements in renal function in subjects with essential hypertension?
Population
6 subjects with essential hypertension, stabilized on a diet containing 100 mmol Na+, 80 mmol K+ and 1650 ml…
Comparison
Nicardipine vs Baseline (prior to treatment)
Design
Case_series
Follow-up
6 weeks
Authors
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Acute renal effects of nicardipine may not persist chronically in essential hypertension; hypothesis-generating for long-term renal hemodynamics.
Does chronic nicardipine therapy maintain the acute improvements in renal function in subjects with essential hypertension?
The acute natriuretic, diuretic, and renal vasodilatory effects of nicardipine do not persist with chronic therapy in essential hypertension, though overall renal function is preserved.
Smith et al. (1987) studied this question.
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