What question did this study set out to answer?

June 1, 1986Clinical CardiologyOpen Access

Acute and chronic effects of nicardipine on systolic and diastolic left ventricular performance in patients with heart failure: A pilot study

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Why the study?

Does nicardipine improve systolic and diastolic left ventricular performance in patients with mild to moderate heart failure?

Population

10 male patients with New York Heart Association Class II and III heart failure

Design

Case_series

Follow-up

4 weeks

Authors

ALAvijit LahiriCardiac Imaging CRChristopher W. RobinsonNorthwick Park Hospital RKRavinder S. KohliNorthwick Park Hospital

Discussion

Member takes

Implication

May warrant randomized trials of nicardipine in HF; too preliminary to change practice.

Key Points

To determine the acute and chronic effects of nicardipine on systolic and diastolic left ventricular function in patients with congestive heart failure.
Ten male patients with NYHA Class II and III congestive heart failure received an acute intravenous infusion of nicardipine (10 mg over 10 minutes).
Eight patients continued chronic oral therapy (20 mg or 40 mg three times daily) for 4 weeks.
Left ventricular ejection fraction, peak filling rate, and relative cardiac output were monitored using a nuclear probe alongside hemodynamics.
Acute infusion lowered blood pressure from 133±26/86±11 to 103±22/69±13 mmHg and raised heart rate from 67±9 to 85±10 beats/min (p < 0.001).
Acute infusion increased left ventricular ejection fraction from 31±7% to 38±6%, relative cardiac output from 24±9 to 41±11, and peak filling rate from 1.18±0.4 to 1.82±0.4 EDV/s (p < 0.001 for all).
At 4 weeks, blood pressure and heart rate returned to baseline, while improvements in ejection fraction, cardiac output, peak filling rate, and functional status were sustained in all 8 patients.

Structured PICO

Does nicardipine improve systolic and diastolic left ventricular performance in patients with mild to moderate heart failure?

Population

10 male patients with New York Heart Association Class II and III heart failure (mild to moderate congestive heart failure)

Intervention

Acute intravenous infusion of nicardipine (10 mg over 10 minutes) followed by 4 weeks of chronic oral treatment (20-40 mg three times daily)

Outcome

Left ventricular ejection fraction, peak filling rate, and relative cardiac output measured by nuclear probesurrogate

Nicardipine acutely and chronically improves systolic and diastolic left ventricular function in patients with mild to moderate heart failure.

Cite This Study

Lahiri et al. (1986) studied this question.

synapsesocial.com/papers/6a880923010a27dee476f08e https://doi.org/10.1002/clc.4960090605

Topics

HFrEF treatment Heart failure

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Acute and chronic effects of nicardipine on systolic and diastolic left ventricular performance in patients with heart failure: A pilot study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Acute and chronic effects of nicardipine on systolic and diastolic left ventricular performance in patients with heart failure: A pilot study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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