Why the study?
Does nicardipine alter acute cardiovascular hemodynamics compared to placebo or nifedipine in normal subjects?
Population
Normal subjects
Comparison
Nicardipine (i.v. 0.5-20 mg or oral 10-40 mg) vs Saline/placebo and nifedipine (20 mg)
Design
RCT, randomized, double-blind
Follow-up
3 hours
Authors
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Nicardipine dosing informs acute BP management choices; confirms comparable effects to nifedipine in healthy subjects.
Does nicardipine alter acute cardiovascular hemodynamics compared to placebo or nifedipine in normal subjects?
Nicardipine produces acute dose-dependent hemodynamic effects similar to nifedipine in normal subjects.
Iliopoulou et al. (1983) studied this question.
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