Key result
IV nicardipine reduces systolic aortic pressure by ~38 mm Hg in hypertensive patients.
Why the study?
The hemodynamic effects of nicardipine in patients with angiographically confirmed coronary heart disease were studied to understand its influence on left ventricular hemodynamics and compliance.
Does intravenous nicardipine alter left ventricular hemodynamics in patients with coronary heart disease?
Population
15 patients with coronary heart disease including 10 normotensive and 5 with mild to moderate hypertension
Comparison
Baseline hemodynamics vs after intravenous nicardipine administration
Design
Cohort study
Authors
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May support IV nicardipine for acute aortic pressure reduction; hypothesis-generating and requires randomized confirmation before practice change.
Does intravenous nicardipine alter left ventricular hemodynamics in patients with coronary heart disease?
Absolute Event Rate: 114% vs 139%
p-value: p=<0.001
Intravenous nicardipine effectively reduces aortic pressure and systemic vascular resistance in both normotensive and hypertensive patients with coronary heart disease.
Engberding et al. (1990) studied Coronary heart disease (n=15). Nicardipine vs. Baseline (before administration) was evaluated on Systolic aortic pressure in normotensive patients (mm Hg) (p=<0.001). Intravenous nicardipine significantly reduced systolic aortic pressure from 139 to 114 mm Hg in normotensive patients and from 166 to 128 mm Hg in hypertensive patients (P<0.001 for both).
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