Why the study?
Does nisoldipine improve recovery of contractile function and reduce the no-reflow phenomenon in globally ischemic rat hearts?
Population
Isolated working rat hearts subjected to 33 min of zero-flow global ischemia and 30-min reperfusion
Comparison
Nisoldipine (1 nM) added 10 min before ischemia vs No drug treatment, vehicle, verapamil before…
Design
Preclinical
Follow-up
30-min reperfusion
Authors
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No immediate clinical role; extends preclinical evidence for nisoldipine in rat ischemia but leaves open human translation.
Does nisoldipine improve recovery of contractile function and reduce the no-reflow phenomenon in globally ischemic rat hearts?
Pre-ischemic administration of nisoldipine improves contractile recovery and reduces the no-reflow phenomenon in isolated rat hearts, likely through vascular mechanisms.
Watts et al. (1990) studied this question.
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