September 1, 1993European Heart Journal
Cardioprotection by nisoldipine: role of timing of administration
Why the study?
Does nisoldipine improve myocardial preservation in isolated rabbit hearts subjected to ischemia and reperfusion?
Population
Isolated and perfused rabbit hearts submitted to 60 min ischaemia (1 ml.min-1) followed by 30 min reperfusion
Comparison
Nisoldipine 10 M delivered either 30 min before… vs Untreated control
Design
Preclinical
Follow-up
30 min reperfusion
Authors
Discussion
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Implication
Preclinical cardioprotection in rabbit hearts should not change practice; leaves open translation to human ischemia-reperfusion injury.
Structured PICO
Does nisoldipine improve myocardial preservation in isolated rabbit hearts subjected to ischemia and reperfusion?
P
Population
Isolated and perfused rabbit hearts submitted to 60 min ischaemia (1 ml.min-1) followed by 30 min reperfusion
I
Intervention
Nisoldipine 10(-9) M delivered either 30 min before ischaemia, at the onset, after 30 min of ischaemia, or during reperfusion only
C
Comparator
Untreated control (implied by comparison of values)
O
Outcome
Recovery of left ventricular pressure during reperfusion, release of creatine phosphokinase (CPK), mitochondrial function, tissue content of ATP and CP, calcium homeostasis, and oxidative stresssurrogate
Nisoldipine provides cardioprotection in isolated rabbit hearts when administered before or at the onset of ischemia, but not when given during reperfusion.
Cite This Study
Ferrari et al. (1993) studied this question.