Energy conservation by nisoldipine in ischaemic heart
Why the study?
Does nisoldipine prevent ATP breakdown in ischemic rat hearts?
Population
Isolated perfused rat hearts (Langendorff model) subjected to ischemia
Comparison
Nisoldipine vs Ischemia without nisoldipine
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
May preserve energy charge in ischemic rat hearts; hypothesis-generating and leaves open human translation.
Structured PICO
Does nisoldipine prevent ATP breakdown in ischemic rat hearts?
P
Population
Isolated perfused rat hearts (Langendorff model) subjected to ischemia
I
Intervention
Nisoldipine (concentrations ranging from 1 nM to 300 nM)
C
Comparator
Ischemia without nisoldipine
O
Outcome
ATP catabolism (efflux of purine nucleosides and oxypurines, and adenine nucleotide levels)surrogate
In a preclinical rat heart model, nisoldipine effectively prevented ATP breakdown and preserved energy charge during ischemia.
Cite This Study
Jong et al. (1984) studied this question.