Why the study?
Does nisoldipine improve intracellular calcium handling and ventricular function during global ischemia and reperfusion in ferret hearts?
Population
9 isovolumic coronary-perfused ferret hearts subjected to global ischemia and reperfusion
Comparison
Nisoldipine 10(-8) M in perfusion buffer vs Control ischemia and reperfusion without…
Design
Preclinical
Follow-up
13 minutes (3 min ischemia and 10 min reperfusion)
Authors
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May support calcium-targeted strategies in ischemia-reperfusion; hypothesis-generating with no clinical translation yet.
Does nisoldipine improve intracellular calcium handling and ventricular function during global ischemia and reperfusion in ferret hearts?
Nisoldipine ameliorates ischemia-induced abnormalities in intracellular calcium handling and improves myocardial function during early reperfusion in a ferret heart model.
Amende et al. (1992) studied this question.
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