Key result
Nisoldipine was approximately 10 times more potent than nifedipine in alleviating coronary vasoconstriction in isolated rat hearts, independent of the vasoconstrictive stimulus.
Why the study?
Does nisoldipine improve coronary relaxation compared to nifedipine in Langendorff-perfused rat hearts?
Population
Langendorff-perfused rat hearts
Comparison
Nisoldipine (1 nM, 10 nM) vs Nifedipine (10 nM, 100 nM)
Design
Preclinical
Authors
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Does not support changing dihydropyridine selection in practice; leaves open translation of rat coronary potency to humans.
Does nisoldipine improve coronary relaxation compared to nifedipine in Langendorff-perfused rat hearts?
Absolute Event Rate: 60% vs 96.4%
In a rat heart model, nisoldipine demonstrated approximately 10-fold greater potency than nifedipine in reversing coronary vasoconstriction regardless of the underlying cause.
Okada et al. (2000) studied Coronary vasoconstriction. Nisoldipine vs. Nifedipine was evaluated on Coronary perfusion pressure. Nisoldipine was approximately 10 times more potent than nifedipine in alleviating coronary vasoconstriction in isolated rat hearts, independent of the vasoconstrictive stimulus.
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