What question did this study set out to answer?

To determine whether nisoldipine differentially modulates vascular reactivity to circulating humoral agonists compared to neurally mediated vasoconstrictor stimuli in intact rats.

March 1, 1985HypertensionOpen Access

Selective antagonism of humoral versus neural vasoconstrictor responses by nisoldipine.

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Why the study?

Does nisoldipine selectively antagonize humoral versus neural vasoconstrictor responses in intact rats?

Population

Intact rats (conscious and anesthetized) instrumented with miniaturized pulsed Doppler flow probes

Comparison

Nisoldipine (0.7 microgram/min) administration vs Responses to humoral and neural vasoconstrictor…

Design

Preclinical

Authors

RLR W LappeUniversity of Iowa KBKirk W. BarronUniversity of North Texas JFJames E. FaberUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Indicates preferential humoral over neural antagonism in rats; hypothesis-generating and should not yet inform practice.

Key Points

To determine whether nisoldipine differentially modulates vascular reactivity to circulating humoral agonists compared to neurally mediated vasoconstrictor stimuli in intact rats.
Conscious and anesthetized rats were surgically instrumented with miniaturized pulsed Doppler flow probes to continuously monitor renal, mesenteric, and hindquarters blood flow.
Vascular responses were recorded following intravenous challenges with angiotensin II (75 and 150 ng/kg), norepinephrine (0.6 and 1.2 µg/kg), and epinephrine (0.6 and 1.2 µg/kg), as well as electrical stimulation of the posterior hypothalamus or greater splanchnic nerve, before and during nisoldipine infusion (0.7 µg/min).
Nisoldipine administration significantly attenuated the pressor and regional vasoconstrictor actions of angiotensin II, norepinephrine, and epinephrine (p < 0.05).
Neurally mediated regional vasoconstrictor responses elicited by electrical stimulation of the posterior hypothalamus or greater splanchnic nerve were unaffected by nisoldipine infusion.

Structured PICO

Does nisoldipine selectively antagonize humoral versus neural vasoconstrictor responses in intact rats?

Population

Intact rats (conscious and anesthetized) instrumented with miniaturized pulsed Doppler flow probes

Intervention

Nisoldipine (0.7 microgram/min) administration

Comparator

Responses to humoral and neural vasoconstrictor stimuli without nisoldipine

Outcome

Vascular reactivity (arterial pressure, renal and mesenteric vascular resistance, and blood flow)surrogate

Nisoldipine exerts preferential antagonistic effects on humoral rather than neural vasoconstrictor stimuli in a rat model.

Cite This Study

Lappe et al. (1985) studied this question.

synapsesocial.com/papers/6a88ed7e46f665d09875fe87 https://doi.org/10.1161/01.hyp.7.2.216

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Selective antagonism of humoral versus neural vasoconstrictor responses by nisoldipine.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Selective antagonism of humoral versus neural vasoconstrictor responses by nisoldipine.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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