Population
Rats with experimentally induced myocardial infarction
Comparison
Myocardial infarction vs Sham-operated rats
Design
Preclinical
Follow-up
2 weeks
Authors
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Should not change clinical practice; hypothesis-generating for post-MI remodeling mechanisms in humans.
Myocardial infarction in rats induces significant cavity dilation, systolic and diastolic dysfunction, and molecular shifts toward a fetal phenotype and collagen activation in non-infarcted myocardium.
Shimizu et al. (1998) studied this question.
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