Why the study?
Does myocardial infarction induce different patterns of late remodeling and collagen turnover in the left and right ventricles of rats with and without heart failure?
Population
Male rats with induced myocardial infarction, categorized into those with signs of heart failure and those…
Comparison
Myocardial infarction induction via ligation of… vs SHAM animals
Design
Preclinical
Follow-up
4 weeks
Authors
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These rat MI findings should not change clinical practice; hypothesis-generating for distinct LV/RV collagen turnover mechanisms in HF.
Does myocardial infarction induce different patterns of late remodeling and collagen turnover in the left and right ventricles of rats with and without heart failure?
Following myocardial infarction in rats, left ventricular fibrosis in those with heart failure is driven by collagen production, whereas right ventricular fibrosis is driven by reduced collagen degradation.
Stefanon et al. (2013) studied this question.
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