Why the study?
Does myocardial infarction alter the sequential expression of angiotensinogen mRNA in the liver and myocardium in rats?
Population
Female Sprague-Dawley rats (body weight 200-250 g)
Comparison
Left coronary artery occlusion vs Sham operation
Design
Preclinical
Follow-up
Up to 3 months
Authors
Loading...
Hypothesis-generating for phased systemic versus local RAS activation post-MI; leaves open translation to timed therapies in patients.
Does myocardial infarction alter the sequential expression of angiotensinogen mRNA in the liver and myocardium in rats?
Systemic (liver) renin-angiotensin system is activated acutely after myocardial infarction, whereas the local (myocardial) system is activated during the chronic phase of remodeling.
Hyo Soo Kim (1999) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: