Key result
Myocardial infarction significantly increased the expression of angiotensin type 1 (AT1) receptors in the rat prostate epithelium by 3.38-fold compared to sham-operated controls.
Why the study?
Does myocardial infarction influence the expression of angiotensin receptors in the rat prostate gland?
Does myocardial infarction influence the expression of angiotensin receptors in the rat prostate gland?
Effect estimate: 3.38-fold increase
Absolute Event Rate: 198.4% vs 58.66%
p-value: p=<0.01
Myocardial infarction induces tissue-specific changes in the expression of angiotensin type 1 receptors in the rat prostate, demonstrating that post-MI systemic RAS activation affects distant non-cardiovascular tissues.
MI may alter prostatic AT1R in rats; leaves open any human clinical relevance or therapeutic implications.
Angiotensin II (AngII) is the biologically active peptide of the renin-angiotensin system (RAS). Tissue- based, local RAS has been identified in the prostate, testis, epididymis and coagulating glands. Experimental and clinical studies have consistently shown that myocardial infarction (MI) is associated with activation of the systemic RAS with increased concentration of angiotensin peptides in the blood and changes in expression of angiotensin receptors (AT). Changes in angiotensin receptors in the renal and cardiovascular system after MI are well recognized, but the effects of MI influence on changes in other tissue like the prostate gland are unknown. In the present study, we investigated the effect of myocardial infarction on angiotensin receptor protein and mRNA expression in the rat prostate gland. MI model was established in Wistar rats by ligating the left coronary artery (modified Selye method). The levels of AT1a-b and AT2 receptor mRNAs and proteins were measured in the rat prostate. Our study demonstrates tissue-specific changes in AT1a-b and AT2 receptor expression after myocardial infarction. The results show that MI has a strong influence on the expression of angiotensin receptor type AT1 in the prostate at the protein and mRNA level.
No takes yet. Share an insight, caveat, or question.
Piastowska‐Ciesielska et al. (2011) studied Myocardial Infarction (n=20). Myocardial infarction (left coronary artery ligation) vs. Sham operation was evaluated on AT1 receptor density in the prostate epithelium (optical density) (3.38-fold increase, p=<0.01). Myocardial infarction significantly increased the expression of angiotensin type 1 (AT1) receptors in the rat prostate epithelium by 3.38-fold compared to sham-operated controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: