Key result
Subdiaphragmatic aortic constriction in rats showed that LV renin varies directly with plasma renin, is confined to the interstitial space, and generates significant intramyocardial angiotensin I.
Population
Rat model of pressure-overload cardiac hypertrophy
Comparison
Subdiaphragmatic aortic constriction (AC) vs Sham-treated rats
Design
Preclinical
Follow-up
42 days
Authors
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Supports interstitial cardiac renin in rat hypertrophy models; leaves open human relevance and clinical translation.
In a rat model of pressure-overload hypertrophy, LV renin varies directly with plasma renin, is confined to the interstitial space, and can generate significant intramyocardial angiotensin I.
Heller et al. (1998) studied pressure-overload cardiac hypertrophy. Subdiaphragmatic aortic constriction (AC) vs. Sham-treated rats was evaluated on Plasma and left ventricular (LV) renin and angiotensinogen concentrations. Subdiaphragmatic aortic constriction in rats showed that LV renin varies directly with plasma renin, is confined to the interstitial space, and generates significant intramyocardial angiotensin I.
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