Key result
Infusion of endothelin-specific antibodies into spontaneously hypertensive rats decreased mean arterial pressure by approximately 10% and increased glomerular filtration rate by approximately 50%.
Why the study?
Do endothelin-specific antibodies decrease blood pressure and improve renal hemodynamics in spontaneously hypertensive rats?
Population
Anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats
Comparison
Intravenous administration of… vs Infusion of normal rabbit serum into SHR, or…
Design
Preclinical
Authors
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Endothelin antibodies merit further preclinical study; leaves open translation to human hypertension or renal disease.
Do endothelin-specific antibodies decrease blood pressure and improve renal hemodynamics in spontaneously hypertensive rats?
Endogenous endothelin plays an important role in maintaining elevated systemic blood pressure and altered renal hemodynamics in spontaneously hypertensive rats.
Ohno et al. (1992) studied Hypertension. Endothelin-specific antibodies vs. Normal rabbit serum was evaluated on Mean arterial pressure, renal vascular resistance, glomerular filtration rate, and renal plasma flow. Infusion of endothelin-specific antibodies into spontaneously hypertensive rats decreased mean arterial pressure by approximately 10% and increased glomerular filtration rate by approximately 50%.
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