Why the study?
Does intrarenal endothelin receptor antagonism improve renal hemodynamic and excretory function in spontaneously hypertensive rats?
Population
14- to 16-week-old spontaneously hypertensive rats (SHR) (n=14) and age-matched Wistar-Kyoto rats (WKY) (n=7)
Comparison
Infusion of PD 145065 and FR 139317 into the… vs Saline infusion into the renal interstitium
Design
Preclinical
Authors
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Endothelin receptor blockade may enhance renal function in hypertensive rat models; leaves open translation to human hypertension.
Does intrarenal endothelin receptor antagonism improve renal hemodynamic and excretory function in spontaneously hypertensive rats?
Endothelin receptor blockade within the kidney improves renal hemodynamic and excretory function in spontaneously hypertensive rats, suggesting a role for intrarenal endothelin in hypertension-related renal abnormalities.
Kato et al. (1995) studied this question.
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