Why the study?
Does bosentan or renal denervation alter kidney function and endothelin-1 expression in normotensive and spontaneously hypertensive rats?
Population
Normotensive Wistar-Kyoto rats and spontaneously hypertensive rats with intact renal nerves and 7 days after…
Comparison
Bosentan and/or renal denervation vs Intact renal nerves and/or normotensive WKY rats
Design
Preclinical
Follow-up
7 days after renal denervation
Authors
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Does not inform clinical use of bosentan or denervation; leaves open endothelin-1's role in hypertensive kidney models.
Does bosentan or renal denervation alter kidney function and endothelin-1 expression in normotensive and spontaneously hypertensive rats?
Impaired renal endothelin-1 synthesis in spontaneously hypertensive rats may contribute to excessive sodium retention and the pathogenesis of hypertension by failing to counteract renal nerve activity.
Girchev et al. (2006) studied this question.
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