Why the study?
Does active immunization against renin reduce blood pressure and left ventricular weight similarly to ACE inhibition in spontaneously hypertensive rats?
Does active immunization against renin reduce blood pressure and left ventricular weight similarly to ACE inhibition in spontaneously hypertensive rats?
Active immunization against renin produces similar cardiovascular effects to chronic ACE inhibition in spontaneously hypertensive rats, suggesting that blockade of the renin-angiotensin system accounts for most of the effects of ACE inhibitors.
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Provides preclinical support for renin immunization; hypothesis-generating for human hypertension trials.
Lo et al. (1990) studied this question.
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