January 1, 2000Hypertension ResearchOpen Access

Renal Protective Effects of Blocking the Intrarenal Renin-Angiotensin System: Angiotensin II Type I Receptor Antagonist Compared with Angiotensin-Converting Enzyme Inhibitor.

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Why the study?

Does AT1RA or ACEI improve renal function and reduce renal damage in rats with experimental nephrotic syndrome?

Structured PICO

Does AT1RA or ACEI improve renal function and reduce renal damage in rats with experimental nephrotic syndrome?

Population

28 SD rats with experimental nephrotic syndrome induced by repeated peritoneal injections of puromycin

Intervention

Angiotensin II type I receptor antagonist (irbesartan) or Angiotensin-converting enzyme inhibitor (enalapril) for 12 weeks

Comparator

Normal control and nephrotic control rats

Outcome

Renoprotective effects including urinary protein, renal function, and glomerular and interstitial damage indexessurrogate

AT1RA and ACEI provide comparable renoprotection in a rat model of nephrotic syndrome by inhibiting intrarenal angiotensin II.

Authors

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Comparable renoprotection by ACEI or AT1RA in rat nephrotic syndrome; leaves open translation to human disease.

Zhou et al. (2000) studied this question.

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