Key result
Long-term blockade of AT1 receptors with L-158,809 in rats with chronic nephritis decreased blood pressure and normalized urinary albumin excretion, being as effective as ACE inhibition.
Why the study?
Does AT1 receptor antagonism or ACE inhibition improve blood pressure and albuminuria in rats with autoimmune nephritis?
Does AT1 receptor antagonism or ACE inhibition improve blood pressure and albuminuria in rats with autoimmune nephritis?
Long-term blockade of AT1 receptors in chronic nephritis is as effective as ACE inhibition in reducing blood pressure and albuminuria, potentially mediated by cGMP production.
Authors
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AT1 blockade matches ACE inhibition for BP and albuminuria in rat nephritis; hypothesis-generating and leaves open human translation.
Uhlenius et al. (2002) studied Chronic experimental nephritis. AT1 receptor antagonist L-158,809 and/or ACE inhibitor captopril vs. Vehicle-treated nephritic group was evaluated on Blood pressure, urinary albumin, and urinary excretion of cGMP. Long-term blockade of AT1 receptors with L-158,809 in rats with chronic nephritis decreased blood pressure and normalized urinary albumin excretion, being as effective as ACE inhibition.
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