Why the study?
Does captopril prevent hypertension, mortality, and renal damage in rats with experimental nephritis and NO synthase inhibition?
Population
Rats with and without autoimmune Heymann nephritis
Comparison
Captopril in drinking water for 12 weeks, with… vs L-NAME alone or no treatment (control)
Design
Preclinical
Follow-up
12 weeks
Authors
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Should not change clinical practice; hypothesis-generating for ACE inhibition in human nephritis with NO synthase inhibition.
Does captopril prevent hypertension, mortality, and renal damage in rats with experimental nephritis and NO synthase inhibition?
In a rat model of experimental nephritis, ACE inhibition with captopril prevented L-NAME-induced hypertension, cardiac hypertrophy, and mortality, suggesting a renoprotective role.
Uhlenius et al. (1999) studied this question.
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