Why the study?
Does captopril improve cardiac hypertrophy and renal damage in NO-deficient hypertensive rats?
Population
Wistar rats treated with the NO synthase inhibitor N(w)-nitro-L-arginine methyl ester (L-NAME)
Comparison
Captopril (10 mg/kg/day) plus L-NAME for 4 weeks vs Untreated group, and group treated with L-NAME…
Design
Preclinical
Follow-up
4 weeks
Authors
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ACEIs may reverse cardiac and renal sequelae in NO-deficient rat hypertension; leaves open translation to human disease.
Does captopril improve cardiac hypertrophy and renal damage in NO-deficient hypertensive rats?
Captopril effectively reverses hypertension, cardiac hypertrophy, and renal damage in a rat model of NO-deficient hypertension.
Khattab et al. (2005) studied this question.
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