Why the study?
Does captopril prevent spontaneous hypertension more effectively than enalapril in spontaneously hypertensive rats?
Population
21 young 6-week-old male spontaneously hypertensive rats (SHR)
Comparison
Captopril 50 mg/kg/day in tap water for 6 weeks vs Enalapril 50 mg/kg/day in tap water for 6 weeks…
Design
Preclinical, randomly divided
Follow-up
6 weeks
Authors
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Captopril appeared more effective than enalapril in this rat model; leaves open whether thiol-containing ACE inhibitors confer advantages in human hypertension.
Does captopril prevent spontaneous hypertension more effectively than enalapril in spontaneously hypertensive rats?
Captopril, an ACE inhibitor containing a thiol group, was more effective than enalapril in preventing hypertension in spontaneously hypertensive rats, likely due to decreased oxidative stress and increased cGMP in the aorta.
O Pecháňová (2007) studied this question.
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