Why the study?
Do thiol-containing compounds prevent venous thrombosis in a rat model?
Population
Rats undergoing ligation of the vena cava
Comparison
Captopril, epicaptopril, N-acetylcysteine, or… vs Distilled water administered per os for 10 days
Design
Preclinical
Follow-up
10 days
Authors
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No immediate clinical implications for venous thrombosis; hypothesis-generating for thiol-dependent antithrombotic effects independent of ACE inhibition.
Do thiol-containing compounds prevent venous thrombosis in a rat model?
Thiol-containing compounds, including captopril, demonstrate antithrombotic activity in rats via a nitric oxide/prostacyclin-dependent mechanism, independent of ACE inhibition.
Pawlak et al. (2000) studied this question.
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