October 31, 2002HypertensionOpen Access

Antithrombotic Effect of Captopril and Losartan Is Mediated by Angiotensin-(1-7)

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Structured PICO

Population

Rats developing venous thrombosis

Intervention

Intravenous infusion of Ang-(1-7) (1, 10, or 100 pmol/kg per minute for 2 hours), captopril, and losartan, with or without various antagonists (A-779, EXP 3174, PD 123,319, L-NAME, indomethacin)

Outcome

Thrombus weightsurrogate

The antithrombotic effects of ACE inhibitors and ARBs are mediated by Ang-(1-7)-evoked release of NO and prostacyclin in a rat model of venous thrombosis.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Provides mechanistic insight into ACEI/ARB antithrombotic actions in rats; leaves open translation to clinical venous thrombosis prevention.

Cite This Study

Kucharewicz et al. (2002) studied this question.

synapsesocial.com/papers/6a718a838031ec7bb1dd02fd https://doi.org/10.1161/01.hyp.0000035396.27909.40

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Implication

Provides mechanistic insight into ACEI/ARB antithrombotic actions in rats; leaves open translation to clinical venous thrombosis prevention.

Antithrombotic Effect of Captopril and Losartan Is Mediated by Angiotensin-(1-7)

Structured PICO

Discussion

Implication

Cite This Study

Antithrombotic Effect of Captopril and Losartan Is Mediated by Angiotensin-(1-7)

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider