Why the study?
Does captopril or enalapril reduce thrombus weight in normotensive rats with experimental venous thrombosis?
Population
Normotensive rats with experimental venous thrombosis induced by ligation of the vena cava
Comparison
Captopril or enalapril administered orally for… vs Distilled water administered orally for 10 days
Design
Preclinical
Follow-up
10 days
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Captopril may exert antithrombotic effects in rat venous thrombosis; hypothesis-generating and should not change clinical practice.
Does captopril or enalapril reduce thrombus weight in normotensive rats with experimental venous thrombosis?
ACE inhibitors, particularly captopril, exhibit antithrombotic effects in a rat model of venous thrombosis, involving nitric oxide and prostacyclin pathways.
A 1998 study studied this question.
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