September 1, 1991Journal of Cardiovascular Pharmacology
Converting Enzyme Inhibitors and the Role of the Sulfhydryl Group in the Potentiation of Exo- and Endogenous Nitrovasodilators
Why the study?
Does captopril improve exercise performance in patients with stable angina pectoris on chronic nitrate treatment?
Population
10 patients with stable, exercise-induced angina pectoris treated for 3 weeks with slow-release isosorbide…
Comparison
Captopril 25 mg administered 1 hour before… vs Placebo administered 1 hour before exercise…
Design
RCT, randomized crossover design, double-blind
Follow-up
1 hour post-dose (days 14 and 21)
Authors
Discussion
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Overview
Supports captopril addition for exercise tolerance in nitrate-treated stable angina; extends ACE inhibitor role in ischemic heart disease.
Structured PICO
Does captopril improve exercise performance in patients with stable angina pectoris on chronic nitrate treatment?
P
Population
10 patients with stable, exercise-induced angina pectoris treated for 3 weeks with slow-release isosorbide dinitrate (20 mg four times daily), exhibiting chest pain and at least 1-mm ST-segment depression on ECG during exercise. (The study also included preclinical experiments on isolated rat hearts).
I
Intervention
Captopril 25 mg administered 1 hour before exercise testing
C
Comparator
Placebo administered 1 hour before exercise testing
O
Outcome
Combined score of maximal ST-segment depression, maximal workload, and time to anginasurrogate
Captopril, a sulfhydryl-containing ACE inhibitor, potentiates the effects of endogenous nitrovasodilators and improves exercise performance in patients with stable angina on chronic nitrate therapy.
Cite This Study
Gilst et al. (1991) studied this question.