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February 1, 1994Cardiovascular Research

Endothelium dependent vasomotor responses to endogenous agonists are potentiated following ACE inhibition by a bradykinin dependent mechanism

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Why the study?

Does ACE inhibition potentiate agonist-induced endothelium-dependent vasodilation in conscious dogs?

Population

Chronically instrumented conscious dogs (n=8)

Comparison

Intracoronary administration of captopril and… vs Intracoronary infusions of acetylcholine…

Design

Preclinical

Authors

JZJohannes ZanzingerPfizer (United States)XZXiaoyan ZhengSouthwest University of Science and TechnologyEBE. BassengeGoethe University Frankfurt

Discussion

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Overview

Hypothesis-generating for bradykinin-mediated ACE inhibitor effects on coronary flow; leaves open human translation.

Structured PICO

Does ACE inhibition potentiate agonist-induced endothelium-dependent vasodilation in conscious dogs?

P
Population
Chronically instrumented conscious dogs (n=8)
I
Intervention
Intracoronary administration of captopril (1 mg/kg) and enalapril (0.4 mg/kg) during intracoronary infusions of acetylcholine, adenosine, and bradykinin, with or without specific antagonists (HOE-140, L-NAME, indomethacin)
C
Comparator
Intracoronary infusions of acetylcholine, adenosine, and bradykinin without ACE inhibitors
O
Outcome
Coronary blood flow and diameter of the left circumflex coronary arterysurrogate

ACE inhibitors enhance endothelium-dependent vasodilation in vivo by facilitating NO and PGI2 release via an endogenous bradykinin-dependent mechanism.

Cite This Study

Zanzinger et al. (1994) studied this question.

synapsesocial.com/papers/6a72bbfbe36a167817e40a98https://doi.org/10.1093/cvr/28.2.209
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Potentiation of endothelium-dependent relaxations to bradykinin by angiotensin I converting enzyme inhibitors in canine coronary artery involves both endothelium-derived relaxing and hyperpolarizing factors.1992 · 223 citations
  2. 2ACE inhibitors are endothelium dependent vasodilators of coronary arteries during submaximal stimulation with bradykinin1993 · 67 citations
  3. 3Endothelium-mediated vasodilation during ACE inhibition1995 · 24 citations
  4. 4Local Potentiation of Bradykinin-Induced Vasodilation by Converting-Enzyme Inhibition in Isolated Coronary Arteries1992 · 33 citations
  5. 5Role of Endothelium-Derived Hyperpolarizing Factor in ACE Inhibitor-Induced Renal Vasodilation in Vivo2004 · 35 citations