February 1, 1993Cardiovascular Research

ACE inhibitors are endothelium dependent vasodilators of coronary arteries during submaximal stimulation with bradykinin

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Why the study?

Do ACE inhibitors potentiate endothelium-dependent vasodilation of coronary arteries in the presence of bradykinin?

Structured PICO

Do ACE inhibitors potentiate endothelium-dependent vasodilation of coronary arteries in the presence of bradykinin?

Population

Isolated bovine and human coronary artery rings

Intervention

ACE inhibitors (lisinopril, enalaprilat, captopril) in the presence of submaximal concentrations of bradykinin or other vasodilators

Comparator

Rings without endothelium, or treated with nitro-l-arginine, bradykinin-2 receptor antagonist Hoe 140, or other vasodilators (acetylcholine, ADP, substance P, SIN-1)

Outcome

Vascular tone (isometric force) and relaxationsurrogate

ACE inhibitors potentiate endothelium-dependent vasodilation to bradykinin in coronary arteries via a local mechanism, independent of systemic kinin accumulation.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Highlights potential local coronary effects of ACE inhibitors; leaves open translation to human disease.

Cite This Study

Auch–Schwelk et al. (1993) studied this question.

synapsesocial.com/papers/6a797b2d1bd2924d66f36b9f https://doi.org/10.1093/cvr/27.2.312

View Full Paper

Ask AI

Bookmark

ACE inhibitors are endothelium dependent vasodilators of coronary arteries during submaximal stimulation with bradykinin

Structured PICO

Discussion

Implication

Cite This Study

ACE inhibitors are endothelium dependent vasodilators of coronary arteries during submaximal stimulation with bradykinin

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider