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February 10, 2004HypertensionOpen Access

Role of Endothelium-Derived Hyperpolarizing Factor in ACE Inhibitor-Induced Renal Vasodilation in Vivo

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Why the study?

Does cilazaprilat induce vasodilation via endothelium-derived hyperpolarizing factor (EDHF) in canine renal microcirculation in vivo?

Population

Canine renal microcirculation in vivo

Design

Preclinical

Authors

HMHiroto Matsudakeiyu HospitalKHKôichi HayashiSt. Marianna University School of MedicineSWShu WakinoTokushima University Hospital

Discussion

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Overview

Suggests EDHF involvement in ACE inhibitor renal vasodilation in dogs; leaves open translation to human hypertension management.

Structured PICO

Does cilazaprilat induce vasodilation via endothelium-derived hyperpolarizing factor (EDHF) in canine renal microcirculation in vivo?

P
Population
Canine renal microcirculation in vivo
I
Intervention
Cilazaprilat (30 microg/kg) administered in the presence of E4177 (an angiotensin receptor blocker), with or without additional blockers (bradykinin receptor antagonist, l-NAME, proadifen)
O
Outcome
Changes in diameter of superficial and juxtamedullary afferent and efferent arteriolessurrogate

ACE inhibitors exert multiple vasodilator mechanisms in the renal microcirculation, including a putative EDHF-mediated vasodilation of juxtamedullary afferent arterioles.

Cite This Study

Matsuda et al. (2004) studied this question.

synapsesocial.com/papers/6a86b868bb0787ff27ca0410https://doi.org/10.1161/01.hyp.0000118053.42262.71
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Potentiation of endothelium-dependent relaxations to bradykinin by angiotensin I converting enzyme inhibitors in canine coronary artery involves both endothelium-derived relaxing and hyperpolarizing factors.1992 · 223 citations
  2. 2Roles of ANG II and bradykinin in the renal regional blood flow responses to ACE inhibition in sodium-depleted dogs2000 · 24 citations
  3. 3Role of Angiotensin II in Activation of the JAK/STAT Pathway Induced by Acute Pressure Overload in the Rat Heart1997 · 156 citations
  4. 4Distinct Modulation of Superficial and Juxtamedullary Arterioles by Prostaglandin in Vivo.2002 · 17 citations
  5. 5Bradykinin attenuates the [Ca2+]i response to angiotensin II of renal juxtamedullary efferent arterioles via an EDHF2001 · 26 citations