Why the study?
Does captopril improve left ventricular relaxation in isolated guinea pig hearts?
Population
Isolated ejecting guinea pig hearts under conditions of constant loading and heart rate (n=31)
Comparison
Captopril with or without bradykinin vs Bradykinin alone, or captopril with nitric oxide…
Design
Preclinical
Authors
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Supports bradykinin/NO-mediated lusitropy with captopril in isolated hearts; leaves open translation to human diastolic function.
Does captopril improve left ventricular relaxation in isolated guinea pig hearts?
Captopril acutely enhances left ventricular relaxation in isolated guinea pig hearts through an endogenous bradykinin/nitric oxide pathway.
Anning et al. (1995) studied this question.
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