Key result
Both nitroglycerin and nicorandil exhibited an increase in vasodilation in human coronary resistance vessels in the presence of an ACE inhibitor containing a sulfhydryl group.
Why the study?
Does the addition of ACE inhibitors with sulfhydryl groups enhance vasodilation induced by nitroxy groups in human coronary resistance vessels in vitro?
Population
Human coronary resistance vessels resected from the right atrial appendage of 27 patients undergoing open…
Comparison
Addition of ACE inhibitors to nitroglycerin or… vs Nitroglycerin or nicorandil alone, or…
Design
Preclinical
Authors
Loading...
Should not change practice; leaves open whether sulfhydryl ACE inhibitors potentiate nitrovasodilators in patients.
Does the addition of ACE inhibitors with sulfhydryl groups enhance vasodilation induced by nitroxy groups in human coronary resistance vessels in vitro?
ACE inhibitors containing a sulfhydryl group enhance the vasodilatory action of nitroxy groups in human coronary resistance vessels, likely via ATP-sensitive potassium channel opening.
Takahashi et al. (2000) studied Patients undergoing open heart surgery (n=27). ACE inhibitors with a sulfhydryl group (captopril) vs. ACE inhibitors without a sulfhydryl group (enalaprilat) was evaluated on Vasodilation of human coronary resistance vessels in vitro. Both nitroglycerin and nicorandil exhibited an increase in vasodilation in human coronary resistance vessels in the presence of an ACE inhibitor containing a sulfhydryl group.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: