Key result
Sulfhydryl alkylating and reducing agents fail to alter nitroglycerin-induced coronary artery relaxation.
Why the study?
Do sulfhydryl reagents affect nitroglycerin-induced relaxation in bovine coronary arterial strips?
Population
Bovine coronary arterial strips submaximally contracted using 30 mM K
Design
Preclinical
Authors
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Little evidence supports sulfhydryl involvement in nitroglycerin relaxation; challenges the hypothesis and leaves open alternative mechanisms in coronary arteries.
Do sulfhydryl reagents affect nitroglycerin-induced relaxation in bovine coronary arterial strips?
The study provides little evidence to support the hypothesis that critical sulfhydryl groups are specifically involved in nitroglycerin-induced relaxation of arterial smooth muscle.
Gruetter et al. (1986) studied this question. Sulfhydryl alkylating and reducing agents was evaluated on Nitroglycerin-induced vascular smooth muscle relaxation. Sulfhydryl alkylating and reducing agents did not selectively inhibit or markedly enhance nitroglycerin-induced relaxation in bovine coronary arteries, providing little evidence for their specific involvement.
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