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July 1, 1987Journal of Cardiovascular Pharmacology

Effects of Glyceryl Trinitrate on Endothelium-Dependent and -Independent Relaxation and Cyclic GMP Levels in Rat Aorta and Human Coronary Artery

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Population

Rat thoracic aorta and human coronary artery tissues

Comparison

Pretreatment with glyceryl trinitrate vs No pretreatment (implied)

Design

Preclinical

Authors

RRRobert M. RapoportUniversity of Cincinnati Medical CenterSWScott A. WaldmanThomas Jefferson UniversityRGRobert GinsburgUniversity of Colorado Hospital

Discussion

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Implication

GTN pretreatment may induce cross-tolerance impairing endothelium-dependent vasodilation; leaves open whether this mechanism drives clinical nitrate tolerance.

Structured PICO

P
Population
Rat thoracic aorta and human coronary artery tissues
I
Intervention
Pretreatment with glyceryl trinitrate
C
Comparator
No pretreatment (implied)
O
Outcome
Relaxations and cyclic GMP levels in response to nitrogen oxide-containing vasodilators, endothelium-dependent vasodilators, and atrial peptidessurrogate

Glyceryl trinitrate-induced desensitization inhibits relaxation and cyclic GMP formation in response to both exogenous nitrates and endogenous endothelium-dependent vasodilators, but not atrial peptides.

Cite This Study

Rapoport et al. (1987) studied this question.

synapsesocial.com/papers/6a8b2157a42d46e0ffcab059https://doi.org/10.1097/00005344-198707000-00012
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of In Vivo Nitroglycerin Therapy on Endothelium-Dependent and Independent Vascular Relaxation and Cyclic GMP Accumulation in Rat Aorta1987 · 128 citations
  2. 2Vasodilation Induced by Acetylcholine and by Glyceryl Trinitrate in Rat Aortic and Mesenteric Vasculature2008 · 26 citations
  3. 3Role of cyclic GMP of canine vascular smooth muscle in relaxation by organic nitrates.1986 · 12 citations
  4. 4Endothelium‐derived relaxing factor and nitroprusside compared in noradrenaline‐ and K+‐contracted rabbit and rat aortae.1988 · 33 citations
  5. 5Effects of sulfhydryl reagents on nitroglycerin-induced relaxation of bovine coronary artery1986 · 34 citations