Effect of captopril and enalapril on endothelial function in hypertensive patients.
Why the study?
Do captopril and enalapril improve endothelium-dependent vasodilation in patients with essential hypertension?
Population
24 patients with essential hypertension and 20 normotensive subjects
Comparison
Captopril or enalapril for 7 to 8 weeks vs Baseline measurements and normotensive controls
Design
RCT, randomization to either captopril or enalapril
Follow-up
7 to 8 weeks
Authors
Discussion
Loading...
Member takes
Overview
Both captopril and enalapril lower BP equivalently in essential hypertension; confirms class efficacy on hemodynamics while baseline endothelial impairment persists.
Structured PICO
Do captopril and enalapril improve endothelium-dependent vasodilation in patients with essential hypertension?
P
Population
24 patients with essential hypertension (mean age 45 +/- 2 years) and 20 normotensive subjects (mean age 47 +/- 1 years)
I
Intervention
Captopril or enalapril for 7 to 8 weeks
C
Comparator
Baseline measurements (before treatment) and normotensive controls
O
Outcome
Endothelium-dependent vasodilation in forearm resistance vessels (assessed by forearm blood flow response to methacholine chloride infusion)surrogate
Hypertensive patients exhibit impaired endothelium-dependent vasodilation at baseline, and both captopril and enalapril effectively reduce mean blood pressure.
Cite This Study
Creager et al. (1994) studied this question.