What does this research mean for the field?

Adequate blood pressure control achieved with the ACE inhibitor enalapril does not normalize endothelial dysfunction in patients with essential arterial hypertension. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

March 1, 2006Angiology

Treatment of Essential Arterial Hypertension with Enalapril Does Not Result in Normalization of Endothelial Dysfunction of the Conduit Arteries

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Why the study?

Does enalapril monotherapy normalize flow-mediated dilation of the brachial artery in patients with essential arterial hypertension?

Population

28 patients with essential arterial hypertension for >2 years, adequately treated with enalapril monotherapy…

Comparison

Enalapril monotherapy for at least 1 year vs 22 age-matched healthy normotensive controls

Design

Cross-sectional

Authors

BEBarbara ErženUniversity of Ljubljana PGPrimož GradišekUniversity of Ljubljana PPPavel PoredošUniversity of Ljubljana

Discussion

Member takes

Implication

Endothelial dysfunction persists despite enalapril and BP control; hypothesis-generating for therapies targeting vascular function in hypertension.

Structured PICO

Does enalapril monotherapy normalize flow-mediated dilation of the brachial artery in patients with essential arterial hypertension?

Population

28 patients (mean age: 55.1 years) with essential arterial hypertension for >2 years, adequately treated with enalapril monotherapy for at least 1 year (BP <140/90 mm Hg), without smoking, hypercholesterolemia, diabetes, or obesity.

Intervention

Enalapril monotherapy for at least 1 year

Comparator

22 age-matched healthy normotensive controls

Outcome

Flow-mediated (endothelium-dependent) dilation (FMD) of the brachial artery assessed by high-resolution ultrasoundsurrogate

Adequate blood pressure control with enalapril monotherapy does not normalize endothelial function in patients with essential hypertension.

Cite This Study

Eržen et al. (2006) studied this question.

synapsesocial.com/papers/6a1e9b5d544bdf605faf13fb https://doi.org/10.1177/000331970605700208

Topics

Hypertension management

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Implication

Endothelial dysfunction persists despite enalapril and BP control; hypothesis-generating for therapies targeting vascular function in hypertension.

Treatment of Essential Arterial Hypertension with Enalapril Does Not Result in Normalization of Endothelial Dysfunction of the Conduit Arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Treatment of Essential Arterial Hypertension with Enalapril Does Not Result in Normalization of Endothelial Dysfunction of the Conduit Arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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