What question did this study set out to answer?

To evaluate the impact of six months of antihypertensive therapy with enalapril versus atenolol on peripheral hemodynamics and large artery compliance.

April 1, 1988American Journal of Hypertension

Stable Improvement in Large Artery Compliance after Long-term Antihypertensive Treatment with Enalapril

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Why the study?

Does enalapril improve peripheral hemodynamics compared to atenolol in patients with mild or moderate essential hypertension?

Population

12 patients with mild or moderate essential hypertension

Comparison

Enalapril for 6 months vs Atenolol for 6 months

Design

Cohort

Follow-up

6 months plus 2 weeks washout

Authors

NLNicola De LucaFederico II University Hospital BRBruno RicciardelliIstituto Clinico Sant'Ambrogio GRG. RosielloUniversity of Naples - L'Orientale

Discussion

Member takes

Implication

Supports ACEI-specific vascular effects beyond BP reduction in hypertension; leaves open outcome benefits pending randomized confirmation.

Key Points

To evaluate the impact of six months of antihypertensive therapy with enalapril versus atenolol on peripheral hemodynamics and large artery compliance.
Studied 12 patients with mild or moderate essential hypertension treated for 6 months with enalapril or atenolol.
Assessed forearm hemodynamics via 2-D pulsed Doppler flowmetry at baseline, at 6 months of therapy, and 2 weeks following treatment withdrawal.
Both enalapril and atenolol achieved a comparable reduction in blood pressure.
Enalapril reduced forearm vascular resistance and increased brachial artery diameter, blood flow, and compliance, whereas atenolol induced no change in these parameters.
Reductions in vascular resistance and increases in arterial compliance achieved by enalapril persisted after a 2-week drug washout period.

Structured PICO

Does enalapril improve peripheral hemodynamics compared to atenolol in patients with mild or moderate essential hypertension?

Population

12 patients with mild or moderate essential hypertension

Intervention

Enalapril for 6 months

Comparator

Atenolol for 6 months

Outcome

Peripheral hemodynamics (vascular resistance, brachial artery diameter, flow, and compliance) assessed by 2-D pulsed Doppler flowmetry at 6 months and 2 weeks post-withdrawalsurrogate

Long-term treatment with enalapril, but not atenolol, improves large artery compliance and reduces vascular resistance in essential hypertension, with effects persisting after drug withdrawal.

Cite This Study

Luca et al. (1988) studied this question.

synapsesocial.com/papers/6a70f88135aa2c282ce24c58 https://doi.org/10.1093/ajh/1.2.181

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Implication

Supports ACEI-specific vascular effects beyond BP reduction in hypertension; leaves open outcome benefits pending randomized confirmation.

Stable Improvement in Large Artery Compliance after Long-term Antihypertensive Treatment with Enalapril

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Stable Improvement in Large Artery Compliance after Long-term Antihypertensive Treatment with Enalapril

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider