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March 1, 1984CirculationOpen Access

Hemodynamic and clinical response to enalapril, a long-acting converting-enzyme inhibitor, in patients with congestive heart failure.

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Why the study?

Does enalapril improve hemodynamic parameters and symptoms in patients with severe congestive heart failure?

Population

9 patients with severe congestive heart failure

Comparison

Enalapril administered short-term and long-term vs Baseline (pre-treatment values)

Design

Case_series

Follow-up

4 weeks

Authors

TLT. Barry LevineHeart Failure / CardiomyopathyMOM. T. OlivariUniversity of California, San FranciscoVGVictoria R GarbergUniversity of Minnesota

Discussion

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Implication

Supports potential short-term hemodynamic benefit in severe HF; hypothesis-generating and requires controlled confirmation.

Structured PICO

Does enalapril improve hemodynamic parameters and symptoms in patients with severe congestive heart failure?

P
Population
9 patients with severe congestive heart failure
I
Intervention
Enalapril (oral angiotensin converting-enzyme inhibitor) administered short-term (up to 24 hours) and long-term (4 weeks)
C
Comparator
Baseline (pre-treatment values)
O
Outcome
Short-term and long-term hemodynamic response (mean arterial pressure, right atrial pressure, pulmonary arterial pressure, pulmonary capillary wedge pressure, total pulmonary resistance, cardiac index)surrogate

Enalapril produces significant short- and long-term hemodynamic improvements in patients with severe congestive heart failure.

Cite This Study

Levine et al. (1984) studied this question.

synapsesocial.com/papers/6a0facd096ccf432805fbcfbhttps://doi.org/10.1161/01.cir.69.3.548

Topics

Heart failureHFrEF treatmentHeart failure hospitalization
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Treatment of Chronic Congestive Heart Failure with Captopril, an Oral Inhibitor of Angiotensin-Converting Enzyme1979 · 273 citations
  2. 2SEQUENTIAL CHANGES IN CIRCULATING LEVELS OF ANGIOTENSIN I AND II, RENIN, AND BRADYKININ AFTER CAPTOPRIL1979 · 37 citations
  3. 3The renin system: Variations in man measured by radioimmunoassay or bioassay1972 · 383 citations
  4. 4Oral Angiotensin-Converting Enzyme Inhibitor in Long-Term Treatment of Hypertensive Patients1979 · 356 citations
  5. 5Role of the renin-angiotensin system in the systemic vasoconstriction of chronic congestive heart failure.1978 · 392 citations