Key result
Enalapril and captopril significantly reduced erythrocyte oxidant stress (TBARS 221 and 206 vs 365 nmol/g Hb/h, P<0.05) and enhanced glutathione-dependent antioxidant defenses in mouse tissues.
Why the study?
Do enalapril and captopril improve glutathione-dependent antioxidant defenses in CF-1 mice?
Population
CF-1 mice (4-mo-old females)
Comparison
Enalapril or captopril in drinking water for 11… vs Control (water without ACE inhibitors)
Design
Preclinical
Follow-up
11 weeks
Authors
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ACEIs enhance antioxidant defenses in mice; leaves open translation to human CV therapy.
Do enalapril and captopril improve glutathione-dependent antioxidant defenses in CF-1 mice?
Absolute Event Rate: 221% vs 365%
p-value: p=<0.05
Enalapril and captopril enhance endogenous glutathione-dependent antioxidant defenses and increase nitric oxide production in mouse tissues.
Cavanagh et al. (2000) studied this question. Enalapril and captopril vs. Control was evaluated on In vitro erythrocyte oxidant stress evaluated by thiobarbituric acid-reactive substances (TBARS) production (p=<0.05). Enalapril and captopril significantly reduced erythrocyte oxidant stress (TBARS 221 and 206 vs 365 nmol/g Hb/h, P<0.05) and enhanced glutathione-dependent antioxidant defenses in mouse tissues.
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