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March 1, 1964The Journal of Experimental MedicineOpen Access

Production of Antirenin to Homologous Renin and Its Effect on Experimental Renal Hypertension

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Why the study?

Does immunization with acetylated homologous renin reduce blood pressure in experimental renal hypertension?

Population

Rats, rabbits, and dogs, including a dog with experimental renal hypertension for more than 6 years.

Comparison

Immunization with acetylated homologous renin. vs Untreated homologous renin.

Design

Preclinical

Authors

SDSharad D. DeodharCleveland ClinicEHErwin HaasCedars-Sinai Medical CenterHGHarry GoldblattFood and Agriculture Organization of the United Nations

Discussion

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Overview

Hypothesis-generating in one hypertensive dog; leaves open any role for renin immunization in human hypertension.

Key Points

  • To determine whether chemical acetylation enables homologous renin to stimulate antirenin antibody production and lower arterial blood pressure in experimental chronic renal hypertension.
  • Extracted and partially purified dog renin on a large scale, and chemically acetylated homologous renin from rats, rabbits, and dogs.
  • Immunized rats, rabbits, and dogs with species-specific acetylated renin via repeated subcutaneous injections.
  • Tracked antirenin development and mean arterial blood pressure in a canine model exhibiting experimental renal hypertension for over six years.
  • Acetylation rendered previously non-antigenic homologous renin immunogenic across rats, rabbits, and dogs, inducing antirenin antibodies active against both untreated and acetylated forms.
  • Repeated subcutaneous injections of acetylated dog renin produced progressive antirenin titers and a corresponding progressive reduction of mean arterial blood pressure to prehypertensive levels in chronic renal hypertension.

Structured PICO

Does immunization with acetylated homologous renin reduce blood pressure in experimental renal hypertension?

P
Population
Rats, rabbits, and dogs, including a dog with experimental renal hypertension for more than 6 years.
I
Intervention
Immunization with acetylated homologous renin (repeated subcutaneous injections).
C
Comparator
Untreated homologous renin.
O
Outcome
Development of antirenin and change in mean arterial blood pressure.surrogate

This early preclinical study demonstrates that the renin-angiotensin system plays a crucial role in maintaining chronic experimental renal hypertension, as immunization against renin lowers blood pressure.

Cite This Study

Deodhar et al. (1964) studied this question.

synapsesocial.com/papers/6a7cc327273accedbda8b39ehttps://doi.org/10.1084/jem.119.3.425

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antibodies to Renin as Proof of the Pathogenesis of Sustained Renal Hypertension1958 · 98 citations
  2. 2A Study of Enzymatic and Antigenic Properties of Renin1963 · 18 citations
  3. 3Antibodies to Rabbit -Globulin After Immunizing with Various Preparations of Autologous -Globulin.1963 · 91 citations
  4. 4STUDIES ON EXPERIMENTAL HYPERTENSION1943 · 14 citations
  5. 5Studies on the Rheumatoid and Related Serum Factors1960 · 126 citations