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Experimental animal study demonstrates blood pressure responses to standardized renin doses in canine models, indicating physiological mechanisms underlying renal hypertension and hormone secretion.
As defined by Goldblatt, Katz, Lewis and Richardson, 1 dog U of renin is that amount which, when injected into a trained, unanesthetized, 10 to 20 kg dog, results in a maximal increase in mean arterial pressure of 30 mm Hg within 3 minutes after the time of injection (15). 2 The "simple-hypophysectomized animal" refers to the dog in which the anterior pituitary has been removed and no other physiological alteration has been made. 2026
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Carpenter et al. (1961) studied this question.
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