Why the study?
Does experimental renal hypertension or intravenous renin injection lead to the formation of a circulating pressor substance (hypertensin) in dogs?
Does experimental renal hypertension or intravenous renin injection lead to the formation of a circulating pressor substance (hypertensin) in dogs?
This study provides early experimental evidence that a circulating pressor substance, termed hypertensin, is present in the systemic blood of dogs with experimental renal hypertension.
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Hypothesis-generating for a humoral pressor in experimental renal hypertension; leaves open translation to human disease and therapy.
Gollan et al. (1948) studied this question.