Population
Normotensive, acute and chronic experimental renal hypertensive, and spontaneous hypertensive dogs; goats
Comparison
Injections of hog kidney extracts containing renin vs Dogs not developing antirenin; control levels
Design
Preclinical
Authors
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Suggests antirenin-driven renin upregulation in dogs; leaves open relevance to human renin-angiotensin modulation.
In dogs, the increase in renal renin following hog renin injection is directly related to the presence of antirenin capable of neutralizing endogenous renin.
Schmid et al. (1962) studied this question.
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