Why the study?
Does a renin-specific antiserum reduce blood pressure and plasma renin activity in canine models of sodium depletion and renovascular hypertension?
Does a renin-specific antiserum reduce blood pressure and plasma renin activity in canine models of sodium depletion and renovascular hypertension?
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This preclinical study establishes the role of the renin-angiotensin system in maintaining blood pressure during sodium depletion and initiating renovascular hypertension.
Antiserum specific for purified canine renal renin was used to inhibit this enzyme in trained, conscious dogs. The antiserum did not affect blood pressure in sodium-replete dogs but decreased plasma renin activity and blood pressure in sodium-depleted animals. The antiserum also reduced blood pressure to control levels concomitant with suppression of plasma renin activity in uninephrectomized dogs with acute renovascular hypertension. These observations establish the role of the renin-angiotensin system in the maintenance of blood pressure in the sodium-depleted state as well as in the initiation of renovascular hypertension.
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Dzau et al. (1980) studied this question.
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