July 1, 1969Proceedings of the National Academy of SciencesOpen Access

Inhibition of the Effects of Angiotensin Ii on Adrenal Steroid Production by Dietary Sodium

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Why the study?

Does a high-sodium diet inhibit the steroidogenic effects of angiotensin II in hypophysectomized dogs?

Population

Conscious, undisturbed hypophysectomized dogs

Comparison

Intravenous infusion of angiotensin II for 48… vs Intravenous infusion of angiotensin II for 48…

Design

Preclinical

Follow-up

48 hours

Authors

WDWarren W. DavisAtlanta Medical Center LBLawrence R. BurwellArmed Forces Institute of Pathology FBFrederic C. BartterUniversity of Iowa

Discussion

Member takes

Implication

High-sodium intake may selectively blunt Ang II steroidogenesis in dogs; leaves open relevance to human sodium–RAAS interactions.

Structured PICO

Does a high-sodium diet inhibit the steroidogenic effects of angiotensin II in hypophysectomized dogs?

Population

Conscious, undisturbed hypophysectomized dogs

Intervention

Intravenous infusion of angiotensin II for 48 hours while receiving 200 mEq of dietary sodium daily

Comparator

Intravenous infusion of angiotensin II for 48 hours while receiving 60 mEq of dietary sodium daily

Outcome

Blood pressure and secretion of aldosterone, corticosterone, and cortisolsurrogate

A high-sodium diet eliminates the steroidogenic action of angiotensin II without affecting its pressor action in dogs.

Cite This Study

Davis et al. (1969) studied this question.

synapsesocial.com/papers/6a882184cb36de311aaa6940 https://doi.org/10.1073/pnas.63.3.718

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Inhibition of the Effects of Angiotensin Ii on Adrenal Steroid Production by Dietary Sodium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of the Effects of Angiotensin Ii on Adrenal Steroid Production by Dietary Sodium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider